Nicotine is highly addictive.[12][13][14] Users become physically and psychologically dependent.[15] Scientists do not know whether e-cigarettes are harmful to humans long-term[16][17] because it is hard to separate the effects of vaping from the effects of smoking when so many people both vape and smoke.[note 4][18] E-cigarettes have not been used widely enough or for long enough to be sure.[19][20][21] For people trying to quit smoking, e-cigarette use alongside prescribed nicotine replacement therapy leads to a higher quit rate.[22][23] For people trying to quit smoking without medical help, e-cigarettes have not been found to raise quit rates
An electronic cigarette consists of an atomizer, a power source such as a battery, and a container for e-liquid such as a cartridge or tank. E-cigarettes have evolved over time, and the different designs are classified in generations. First-generation e-cigarettes tend to look like traditional cigarettes and are called "cigalikes".[26][27] Second-generation devices are larger and look less like traditional cigarettes.[28] Third-generation devices include mechanical mods and variable voltage devices.[26] The fourth-generation includes sub-ohm tanks (meaning they have electrical resistance of less than 1 ohm) and temperature control.[29] There are also pod mod devices that use protonated nicotine, rather than free-base nicotine found in earlier generations,[30] providing higher nicotine yields
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